Current Date 25 Dec, 2024

Why do we lose muscle mass with age? Scientists find one factor

Age-related mitochondrial DNA (mtDNA) deletion mutations cause muscle loss. These deletions lead to aberrant gene expression, accelerating aging in humans and rodents. Mitochondria, cellular powerhouses, rely on mtDNA for function. Deletion mutations disrupt ATP production, causing cell death and muscle mass decline. Research suggests these mutations are significant indicators of biological aging.